New Haven is a city in south central Connecticut on New Haven Harbor and the Long Island Sound. The Quinnipiac Indians, specifically the Momauguin band of the Algonquin-speaking Tribe, were the area’s original inhabitants. The Quinnipiacs lived along the banks of Connecticut's many rivers; fittingly, Quinnipiac means long water country. After Dutch explorer Adrian Block first sailed up the Connecticut River in 1614, Quinnipiac lands and peoples began to dwindle, especially as English settlement expanded. In 1638, Reverend John Davenport and Theophilus Eaton, a London merchant, sailed into New Haven Harbor from Massachusetts Bay Colony and formally established New Haven as a Puritan settlement. Though he did not have a royal charter for his new colony, Davenport signed a treaty with Quinnipiac sachem Momauguin in 1738, which gave the English formal ownership over the land. Davenport had left Massachusetts in the midst of the Anne Hutchinson controversy, likely coming to Connecticut to found his own Puritan theocracy. New Haven existed as its own colony distinct from Connecticut until 1665, when Charles II united the two under the Colony of Connecticut. From then on, New Haven referred to the city specifically, which in 1701 became the co-capital of Connecticut along with Hartford. In 1716, the college that would become Yale, where Eleazar Wheelock received his degree in 1733, moved to its permanent home in New Haven. From its creation, Yale was committed to training Christian missionaries; several of Wheelock’s Anglo-American missionaries studied at Yale while many of his Anglo-American students from Moor’s went on to study there. Wheelock took Occom to New Haven in 1744 to see Yale's commencement exercises, but due to terrible eye strain, Occom never attended the College. Because New Haven was the co-capital of Connecticut, any of Occom's or Wheelock’s dealings with the Colony of Connecticut often involved New Haven. By the Revolutionary War, the city had a population of 3,500, almost none of whom were Quinnipiac Indians. New Haven remained co-capital of Connecticut until 1873, when it lost to Hartford in what is known as the "single capital contest."

Allyn Mather was an Anglo-American charity scholar at Moor’s Indian Charity School who had a brief career as a minister before succumbing to illness. Mather arrived at Moor’s in 1766 and entered Yale in 1767. He had a strong distaste for the college: hazing bothered him, and he found the atmosphere singularly unreligious (his dislike was not fleeting: in 1778, he wrote to the Connecticut Courant to criticize the college course of study). Mather volunteered for missions in 1768. He accompanied Ralph Wheelock on his ill-fated third trek to Oneida territory, where Ralph acted intemperately at the tribal council at Onaquaga. Mather then attended Fort Stanwix with Rev. Ebenezer Cleaveland to try to patch up the damage done to Eleazar Wheelock’s agenda by Jacob Johnson. After his adventures, Mather returned to Yale, where he obtained his degree in 1771. However, he did not return to the missionary business: instead, in 1772, he became the pastor of Fair Haven Church, or Fourth Presbyterian, in New Haven, CT. It was a conservative Old Light (or more properly, Old Side) church, largely populated by parishioners who had defected from Jonathan Edwards’ congregation. It is unclear how strongly Mather himself identified with Old Side beliefs; he seems to have described the church to Wheelock as “despised” (773208), but he may have used strong language because he was trying to get out of paying his debt as a defunct charity scholar. Wheelock never seems to have collected from him, nor did he pursue Mather as vigorously as he pursued some other students. In 1779, Mather began having serious health issues, which forced him to travel south regularly. He died in 1784 on one such trip, in Savannah, Georgia.

Eleazar Wheelock was a New Light Congregationalist minister who founded Dartmouth College. He was born into a very typical Congregationalist family, and began studying at Yale in 1729, where he fell in with the emerging New Light clique. The evangelical network that he built in college propelled him to fame as an itinerant minister during the First Great Awakening and gave him many of the contacts that he later drew on to support his charity school for Native Americans. Wheelock’s time as an itinerant minister indirectly brought about his charity school. When the Colony of Connecticut retroactively punished itinerant preaching in 1743, Wheelock was among those who lost his salary. Thus, in 1743, he began operating a grammar school to support himself. He was joined that December by Samson Occom, a Mohegan Indian, who sought out an education in hopes of becoming a teacher among his people. Occom’s academic success inspired Wheelock to train Native Americans as missionaries. To that end, he opened Moor’s Indian Charity School in 1754 (where he continued to train Anglo-American students who paid their own way as well as students who functionally indentured themselves to Wheelock as missionaries in exchange for an education). Between 1754 and 1769, when he relocated to New Hampshire, Wheelock trained approximately 60 male and female Native American students from nearby Algonquian tribes and from the Haudenosaunee (Iroquois) of central New York. At the same time, he navigated the complicated politics of missionary societies by setting up his own board of the Society in Scotland for Propagating Christian Knowledge, although he continued to feud with the Boston Board of the SSPCK and the London Commissioners in Boston (more colloquially called the New England Company). By the late 1760s, Wheelock had become disillusioned with the idea of Native American education. He was increasingly convinced that educating Native Americans was futile (several of his students had failed to conform to his confusing and contradictory standards), and, in late 1768, he lost his connection to the Haudenosaunee. With his inclination and ability to sponsor Native American missionaries largely depleted, Wheelock sought instead to fulfill his ultimate ambition of obtaining a charter and opening a college, which he did in 1769. To fund this new enterprise, Wheelock drew on the £12,000 that Samson Occom had raised for Moor’s Indian Charity School during a two-and-a-half year tour of Great Britain (1765 to 1768). Much of this money went towards clearing land and erecting buildings in New Hampshire for the Charity School’s relocation — infrastructure that also happened to benefit Dartmouth. Many of Wheelock’s contemporaries were outraged by what they saw as misuse of the money, as it was clear that Dartmouth College was not intended for Indians and that Moor’s had become a side project. Although Wheelock tried to maintain at least some commitment to Native American education by recruiting students from Canadian communities, the move did a great deal of damage to his public image. The last decade of Wheelock’s life was not easy. In addition to the problems of trying to set up a college far away from any Anglo-American urban center, Wheelock experienced the loss of relationships with two of his most famous and successful students, Samson Occom and Samuel Kirkland (an Anglo-American protégé). He also went into debt for Dartmouth College, especially after the fund raised in Britain was exhausted.