The Delaware Tribe, or Lenape Tribe, is a conglomeration of linguistically and culturally similar Native American groups that initially inhabited the mid-Atlantic region, including New Jersey, Pennsylvania, eastern Connecticut, and southeastern New York. The three main groups comprising the Delawares are the Munsees, Unamis, and Unalaqtgos. Several Delawares attended Moor’s Indian Charity School, including some of Wheelock’s earliest students. Because the Delawares were not a politically unified entity, contact with Europeans and subsequent conflict over land and trade proved especially devastating for them. During 17th-century battles over trade access, the Delawares found themselves in conflict with the Dutch and the English as well as with other Native American groups that wanted to trade with Europeans. By the time the Dutch left in the mid-17th century, the Delawares were tributaries of the Haudenosaunee (Iroquois). Scholars estimate that by 1750, through a combination of war and disease, the Delaware population had fallen by as much as 90 percent. Many Delawares responded to the situation by leaving. Some migrated west with Moravian missionaries; others joined different tribes, including the Cayugas in New York and the Stockbridge Mahicans in Massachusetts (who later migrated to Oneida territory, near Brothertown, NY, and from thence to Wisconsin). Still others migrated to Ohio and ended up in Kansas or Oklahoma as a result of American expansion. Those who stayed oversaw a century of complex treaty negotiation, including two of the more egregious instances of Native American dispossession: the infamous "walking treaty" between the Delawares and the colony of Philadelphia in 1686, and the American government's (unfulfilled) promise to give the Delawares their own fully-enfranchised state in the union for their support during the Revolution. The Delawares played an important role in the history of Moor’s Indian Charity School. John Brainerd, a Presbyterian missionary to the Delaware and a friend of Wheelock’s, sent Wheelock his first “planned” Native American students from among the Delawares in 1754. J. Brainerd also oversaw the establishment of a Christian Delaware settlement at Brotherton, New Jersey in 1758 (not to be confused with Brothertown in Oneida, New York).

Lebanon is a town located in the state of Connecticut southwest of the town of Hartford. The land that became Lebanon was inhabited at least 10,000 years ago based on the archeological record. By the 1600s, the land was permanently inhabited by the Mohegan Indians, who used the area primarily for hunting. Lebanon was officially formed in 1700 when English settlers consolidated a number of land tracts, including several land grants by the Connecticut General Assembly and lands purchased from the Mohegans. However, these purchases were controversial. In 1659, the Mohegans entrusted their reserve land to Major John Mason, and in the following year, Mason transferred this land to the Connecticut colonial government with the understanding that there would be enough land left for the Mohegans to farm. The Mohegans claimed that they never authorized a transfer to the colonial government and only Mason’s heirs were entrusted with their land. In 1662, Connecticut, which included the Mohegan land that had been entrusted to the Masons, was incorporated by a royal charter. Based on this charter, the colony argued that the land was now the property of the government. In 1687, the colony began granting the Mohegan land to townships, and in 1704 the Masons petitioned the Crown on behalf of the Mohegans, claiming that such transfers of land to townships were illegal. Between the years of 1705 and 1773 legal disputes and controversies persisted, finally ending in a verdict by the Crown against the Mohegans. In 1755, Wheelock received property and housing in Lebanon that he would use as his house and school. While Lebanon was originally incorporated as a part of New London County in 1700, in 1724 it became a part of New Windham, before once again becoming a part of New London County in 1826. Lebanon was central to the American Revolution with half of its adult population fighting for the colonists and hundreds of meetings convened in the town for the revolutionary cause.

Hezekiah Calvin was one of Eleazar Wheelock's first Native American students. Like Wheelock’s other early Delaware students, he was sent by the minister John Brainerd. Calvin was certified as a schoolteacher on March 12, 1765, and was sent to the Mohawks at Fort Hunter in June 1765. The Mohawks threw him out at the end of September 1766, and he returned to Moor's. Samuel Johnson, an Anglo-American Yale student who replaced Calvin at Fort Hunter, reported that the residents unanimously accused Calvin of being abusive and rude. Calvin, in turn, maintained that the Fort Hunter Mohawks had mistreated him. Calvin’s second stint at Moor’s did not go well. He wrote several confessions for drunkenness and bad behavior, and frequently spoke ill of Wheelock. He left the school in the spring of 1768, and took up residence with the Secutor family (Narragansett) at Charlestown, Rhode Island. Calvin left the Narragansetts sometime late in 1768, presumably after the dissolution of his relationship with Mary Secutor. Wheelock heard reports early in 1769 that Calvin had been imprisoned at Little Ease, NJ, for forging a pass for a Black man (Calvin does not appear in the county records, so either he was never indicted or Wheelock had his information wrong). By 1777, Calvin was in a position of prominence at Brotherton, NJ (a town of Christian Delawares founded under John Brainerd’s ministry). At some point after 1788, Calvin moved west with the Delawares: he may have moved directly to join the Delawares in Ohio territory, or he may have relocated to Stockbridge in 1802 and then moved west.

Eleazar Wheelock was a New Light Congregationalist minister who founded Dartmouth College. He was born into a very typical Congregationalist family, and began studying at Yale in 1729, where he fell in with the emerging New Light clique. The evangelical network that he built in college propelled him to fame as an itinerant minister during the First Great Awakening and gave him many of the contacts that he later drew on to support his charity school for Native Americans. Wheelock’s time as an itinerant minister indirectly brought about his charity school. When the Colony of Connecticut retroactively punished itinerant preaching in 1743, Wheelock was among those who lost his salary. Thus, in 1743, he began operating a grammar school to support himself. He was joined that December by Samson Occom, a Mohegan Indian, who sought out an education in hopes of becoming a teacher among his people. Occom’s academic success inspired Wheelock to train Native Americans as missionaries. To that end, he opened Moor’s Indian Charity School in 1754 (where he continued to train Anglo-American students who paid their own way as well as students who functionally indentured themselves to Wheelock as missionaries in exchange for an education). Between 1754 and 1769, when he relocated to New Hampshire, Wheelock trained approximately 60 male and female Native American students from nearby Algonquian tribes and from the Haudenosaunee (Iroquois) of central New York. At the same time, he navigated the complicated politics of missionary societies by setting up his own board of the Society in Scotland for Propagating Christian Knowledge, although he continued to feud with the Boston Board of the SSPCK and the London Commissioners in Boston (more colloquially called the New England Company). By the late 1760s, Wheelock had become disillusioned with the idea of Native American education. He was increasingly convinced that educating Native Americans was futile (several of his students had failed to conform to his confusing and contradictory standards), and, in late 1768, he lost his connection to the Haudenosaunee. With his inclination and ability to sponsor Native American missionaries largely depleted, Wheelock sought instead to fulfill his ultimate ambition of obtaining a charter and opening a college, which he did in 1769. To fund this new enterprise, Wheelock drew on the £12,000 that Samson Occom had raised for Moor’s Indian Charity School during a two-and-a-half year tour of Great Britain (1765 to 1768). Much of this money went towards clearing land and erecting buildings in New Hampshire for the Charity School’s relocation — infrastructure that also happened to benefit Dartmouth. Many of Wheelock’s contemporaries were outraged by what they saw as misuse of the money, as it was clear that Dartmouth College was not intended for Indians and that Moor’s had become a side project. Although Wheelock tried to maintain at least some commitment to Native American education by recruiting students from Canadian communities, the move did a great deal of damage to his public image. The last decade of Wheelock’s life was not easy. In addition to the problems of trying to set up a college far away from any Anglo-American urban center, Wheelock experienced the loss of relationships with two of his most famous and successful students, Samson Occom and Samuel Kirkland (an Anglo-American protégé). He also went into debt for Dartmouth College, especially after the fund raised in Britain was exhausted.

John Brainerd was an ardent missionary with an important role in Wheelock's design. He was the younger brother of the famous missionary David Brainerd, who died as a young man after being expelled from Yale and serving as a missionary to New Jersey tribes. John completed his Yale degree and was immediately commissioned to replace David. Even in his own time, he was seen as a man as pious as, but less talented than, his brother, though Brainerd missioned to Indians during a more volatile period, and saw his congregation forcibly removed from their lands in 1755 and relocated at Brothertown in 1758 (this Brothertown should not be confused with the one founded in New York after the Revolution by many Moor's alumni). Brainerd was extremely devoted to the Indian cause. He often had the opportunity to serve wealthy English congregations, but preferred to remain an Indian missionary. He invested signficant sums of his own money into his missions, for which he was never reimbursed. Brainerd was a very prominent Presbyterian figure, active in the Presbytery and Synod of New York, holding several elected positions, and in the Presbtery and Synod of New York and Philadelphia once the two reunified in 1758. He was a Trustee of the College of New Jersey from 1754 until his death, and a member of the New York Board of the Society in Scotland for Propagating Christian Knowledge. Occom had planned to work with Brainerd in 1750, but political upheaval prevented it. Brainerd was one of several men nominated to accompany Occom to England, but the New York Board refused to let him go. While Brainerd and Wheelock were not close personal friends, the two had a similar interests and a long-lasting correspondence. John Brainerd sent Wheelock his first Indian boys, and also recruited female students in the 1760s. Throughout their lives, Brainerd and Wheelock updated one another on Indian missions, and Brainerd seems to have been one of Wheelock's "point people" in the Presbyterian Church.

David Brainerd was a Presbyterian missionary who became a New Light martyr and inspired Wheelock to work for Native American education. He was the older brother of the longer-lived but lesser-known John Brainerd, who provided Wheelock with his first Native students. In the early 1740s, David got caught up in the New Light tide at Yale, and was subsequently expelled for describing men in positions of authority as unsaved. Because ministers to English congregations had to have a degree from Harvard or Yale, David became a missionary to Native Americans instead. His missions attracted substantial attention, and in 1744 the Newark Presbytery ordained him so that he could receive funding from the Society in Scotland for Propagating Chrisitian Knowledge (SSPCK). Between April 1743 and November 1746, when he became too ill to serve, David conducted missionary efforts among various tribes in the mid-Atlantic region, most notably in New Jersey. After his death from tuberculosis in 1747, David became something of a martyr. New Light Congregationalists, especially, saw David's expulsion from Yale as unjust and his commitment to Native Americans as divine. In 1749, Jonathan Edwards published a biography of David together with David's diary, and the text quickly became part of the New Light canon. Education was central to David Brainerd's ministry, and he was among Wheelock's several inspirations. In 1745, Brainerd sent Wheelock a copy of his journal.